Genetic Risk For Substance Use Can Be Neutralized By Good Parenting

Brody and his colleagues, which include UGA Institute for Behavioral Research director Steven Beach and University of Iowa Associate Professor of Psychiatry Robert Philibert, focused their attention on a gene known as 5HTT that’s involved in the transport of the brain chemical serotonin. Most people carry two copies of the long version of the gene, but those with one or two copies of the short version have been shown in several studies to have a greater likelihood of consuming alcohol and other substances and to have higher levels of impulsivity and risk taking.

The researchers interviewed 253 African-American families in rural Georgia over a four-year period. After obtaining informed consent from the parents and youth, they collected saliva samples for genetic testing.

The researchers found that nearly 60 percent of the youth had two copies of the long gene, while the remainder had one or two copies of the short gene that confers risk. As expected, the use of substances was low among 11 year-olds and increased as the youth aged. By age 14, 21 percent of the youth had smoked cigarettes, 42 percent had used alcohol, five percent had drank heavily and five percent had used marijuana.

Among youth with the genetic risk factor, those who received low levels of involved and supportive parenting increased their substance use at rate three times higher than youth with high levels of parental support. Among youth with high levels of involved and supportive parenting, the difference in substance abuse was negligible – regardless of genetic risk.

“In families that were characterized by strong relationships between children and their parents, the effect of the genetic risk was essentially zero,” said Beach, who is also a Distinguished Research Professor in the psychology department of the UGA Franklin College of Arts and Sciences. “With this study and previous studies looking at environmental risk factors such as poverty, we’re finding that in many cases the best way to help children is to help families become more resilient.”

Interesting. What I am still curious about is whether the parents were notified if their children had the short version of the gene, and if so did it make them more likely to be good parents?

I think genome sequencing services like 23andMe will be a valuable tool for parents, as they will be able to greater understand the risks their children face based on the child's specific genes, and modify the way they parent accordingly.

via ScienceDaily